Title: Sparse but selective and potent synaptic transmission from the globus pallidus to the subthalamic nucleus Running title: Sparse but potent pallidosubthalamic transmission
نویسندگان
چکیده
Jérôme Baufreton1,2, Erin Kirkham1, Jeremy F. Atherton1, Ariane Menard1, Peter J. Magill3, J. Paul Bolam3, Mark D. Bevan1,3 1 Northwestern University, Department of Physiology, 303 E. Chicago Avenue, Chicago IL 60611, USA; 2 Université de Bordeaux 2; CNRS: UMR 5227, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France; 3 Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Mansfield Road, Oxford, OX1 3TH, UK.
منابع مشابه
Sparse but selective and potent synaptic transmission from the globus pallidus to the subthalamic nucleus.
The reciprocally connected GABAergic globus pallidus (GP)-glutamatergic subthalamic nucleus (STN) network is critical for voluntary movement and an important site of dysfunction in movement disorders such as Parkinson's disease. Although the GP is a key determinant of STN activity, correlated GP-STN activity is rare under normal conditions. Here we define fundamental features of the GP-STN conn...
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Reciprocally connected GABAergic neurons of the globus pallidus (GP) and glutamatergic neurons of the subthalamic nucleus (STN) are a putative generator of pathological rhythmic burst firing in Parkinson's disease (PD). Burst firing of STN neurons may be driven by rebound depolarization after barrages of GABA(A) receptor (GABA(A)R)-mediated IPSPs arising from pallidal fibers. To determine the c...
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Excessive burst firing in the dopamine-depleted basal ganglia correlates with severe motor symptoms of Parkinson's disease that are attenuated by high frequency electrical stimulation of the subthalamic nucleus (STN). Here we test the hypothesis that pathological bursts in dopamine-deprived basal ganglia are generated within the STN and transmitted to globus pallidus neurons. To answer this que...
متن کاملNeurobiology of Disease Conditions for the Generation of Beta Oscillations in the Subthalamic Nucleus–Globus Pallidus Network
The advance of Parkinson’s disease is associated with the existence of abnormal oscillations within the basal ganglia with frequencies in the beta band (13–30 Hz). While the origin of these oscillations remains unknown, there is some evidence suggesting that oscillations observed in the basal ganglia arise due to interactions of two nuclei: the subthalamic nucleus (STN) and the globus pallidus ...
متن کاملActivation of group III mGluRs inhibits GABAergic and glutamatergic transmission in the substantia nigra pars reticulata.
The GABAergic projection neurons of the substantia nigra pars reticulata (SNr) exert an important influence on the initiation and control of movement. The SNr is a primary output nucleus of the basal ganglia (BG) and is controlled by excitatory inputs from the subthalamic nucleus (STN) and inhibitory inputs from the striatum and globus pallidus. Changes in the output of the SNr are believed to ...
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تاریخ انتشار 2009